2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-143825
    t-Boc-Aminooxy-PEG11-amine 1630094-83-5
    t-Boc-Aminooxy-PEG11-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    t-Boc-Aminooxy-PEG11-amine
  • HY-132026
    Benzyl-PEG6-MS 1262681-32-2
    Benzyl-PEG6-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG6-MS
  • HY-W190729
    Thiol-PEG3-acetic acid 200291-35-6
    Thiol-PEG3-acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thiol-PEG3-acetic acid
  • HY-140063
    Propargyl-PEG4-CH2-methyl ester 1872433-63-0
    Propargyl-PEG4-CH2-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG4-CH2-methyl ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG4-CH2-methyl ester
  • HY-125392
    2-(Biotin-amido)-1,3-bis-(C1-PEG1-acid) 2086689-02-1
    2-(Biotin-amido)-13-bis(carboxylethoxy)propane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    2-(Biotin-amido)-1,3-bis-(C1-PEG1-acid)
  • HY-140569
    N-(PEG1-OH)-N-Boc-PEG2-propargyl 2100306-85-0
    N-(PEG1-OH)-N-Boc-PEG2-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(PEG1-OH)-N-Boc-PEG2-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    N-(PEG1-OH)-N-Boc-PEG2-propargyl
  • HY-141277
    Methyltetrazine-amido-PEG7-azide 2112731-46-9
    Methyltetrazine-amido-PEG7-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Methyltetrazine-amido-PEG7-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Methyltetrazine-amido-PEG7-azide
  • HY-126676
    DBCO-(PEG2-Val-Cit-PAB)2
    DBCO-(PEG2-Val-Cit-PAB)2 is a dual cleavable ADC linker for antibody-drug conjugates (ADCs). DBCO-(PEG2-Val-Cit-PAB)2 is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-(PEG2-Val-Cit-PAB)2 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-(PEG2-Val-Cit-PAB)2
  • HY-140290
    DBCO-PEG2-NH-Boc 2377004-08-3
    DBCO-PEG2-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG2-NH-Boc is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG2-NH-Boc
  • HY-132110
    Fmoc-N-amido-PEG3-azide 1172605-58-1
    Fmoc-N-amido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Fmoc-N-amido-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Fmoc-N-amido-PEG3-azide
  • HY-140430
    Boc-Aminooxy-PEG1-azide 2100306-67-8
    Boc-Aminooxy-PEG1-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-Aminooxy-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Boc-Aminooxy-PEG1-azide
  • HY-117100
    Propargyl-PEG14-OH
    Propargyl-PEG14-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG14-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG14-OH
  • HY-138316
    THP-PEG10-C2-Boc
    THP-PEG10-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    THP-PEG10-C2-Boc
  • HY-140734
    DSPE-PEG-Amine, MW 3400
    DSPE-PEG-Amine, MW 3400 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DSPE-PEG-Amine, MW 3400
  • HY-140902
    rel-Biotin-PEG3-C3-NH2 1374658-86-2
    rel-Biotin-PEG3-C3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    rel-Biotin-PEG3-C3-NH2
  • HY-141135
    Propargyl-PEG4-tetra-Ac-beta-D-galactose 1397682-61-9
    Propargyl-PEG4-tetra-Ac-beta-D-galactose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Propargyl-PEG4-tetra-Ac-beta-D-galactose
  • HY-130491
    DNP-NH-PEG4-C2-Boc 1817735-31-1
    DNP-NH-PEG4-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DNP-NH-PEG4-C2-Boc
  • HY-138344
    MS-PEG10-THP 42607-91-0
    MS-PEG10-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    MS-PEG10-THP
  • HY-159538
    COOEt-bicyclo[2.2.2]octane-CHO 959958-67-9
    PROTAC SMARCA2 degrader-6-Linker is a PROTAC linker that connects the E3 ligase ligand and the SMARCA2 ligand to form PROTAC SMARCA2 degrader-6 (HY-159448).
    COOEt-bicyclo[2.2.2]octane-CHO
  • HY-133324
    m-PEG37-acid 2924199-92-6
    m-PEG37-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG37-acid
PROTAC Linkers Isoform Comparison

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